Fascicularones A and B from a Mycelial Culture of Naematoloma fasciculare
- Author: mycolabadmin
- 2004-02-01
- View Source
Summary
Scientists discovered two new chemical compounds from a poisonous mushroom found in Japan. Using advanced laboratory techniques, they isolated and identified these compounds from mushroom cultures grown in the lab. This research helps us better understand the chemistry of mushrooms and their potential applications.
Impacts on everyday life:
• Advances our knowledge of mushroom compounds that could lead to new drug discoveries
• Helps identify toxic and beneficial compounds in mushrooms for food safety
• Contributes to understanding how mushrooms produce biologically active substances
• Demonstrates new methods for studying natural compounds from fungi
Background
Naematoloma fasciculare is a bitter poisonous mushroom widely distributed in northeast Japan. Previous research identified six lanostane triterpenoids (fasciculols A-F) and three fasciculol esters with various biological activities including antimicrobial properties and calmodulin inhibition. Some compounds were identified as toxic principles of this mushroom.
Objective
To investigate the chemical constituents from liquid culture of Naematoloma fasciculare and study the biogenetic relationship between components of the mycelium and fruiting body, with particular interest in identifying nontoxic biologically active substances.
Results
Two novel sesquiterpenoids, named fascicularones A and B, were isolated from the culture broth. The compounds were found to contain cis-fused four-member ring moiety in their structures, showing structural similarities to previously isolated naematolins.
Conclusion
The researchers successfully isolated and characterized two new sesquiterpenoids (fascicularones A and B) from N. fasciculare mycelial culture. These compounds contain distinctive cis-fused four-member ring structures that show similarities to previously identified naematolins, suggesting potential biosynthetic relationships.
- Published in:Phytochemistry,
- Study Type:Laboratory Research,
- Source: 10.1016/j.phytochem.2003.10.002