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Exploring the health benefits of Ganoderma: antimicrobial properties and mechanisms of action

Summary

Ganoderma is a medicinal mushroom that has been used in traditional medicine for thousands of years and shows promise as a natural antibiotic. The mushroom contains special compounds like polysaccharides and triterpenoids that can kill harmful bacteria and fungi by damaging their cell walls and boosting your immune system. Recent research shows it works against common infections like those caused by staph bacteria and E. coli, and may even help fight antibiotic-resistant germs.

Background

Ganoderma is a well-known medicinal mushroom used for thousands of years in traditional East Asian medicine. The genus has gained significant attention in modern research for its bioactive compounds exhibiting various pharmacological activities, particularly antimicrobial properties in an era where antimicrobial resistance poses a significant global health threat.

Objective

This review focuses on the mechanisms of action and bioactive compounds responsible for Ganoderma’s ability to inhibit various pathogenic microorganisms. The objective is to synthesize recent findings and highlight emerging insights into the role of Ganoderma as a promising natural antimicrobial agent.

Results

Polysaccharides, triterpenoids, proteins, and phenolic compounds in Ganoderma exhibit strong antimicrobial effects by targeting bacterial cell walls, disrupting membrane integrity, and inhibiting key microbial enzymes. These compounds are effective against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and various fungi, with synergistic effects enhancing therapeutic potential.

Conclusion

Ganoderma represents a promising natural source of antimicrobial agents with potential clinical applications. While in vitro and in vivo studies strongly support its antimicrobial properties, large-scale clinical trials are needed to confirm efficacy. Establishing standardized dosages and exploring molecular pathways will be key to incorporating Ganoderma into clinical practice for infection control.
  • Published in:Frontiers in Cellular and Infection Microbiology,
  • Study Type:Review,
  • Source: PMC12313647, PMID: 40756033, DOI: 10.3389/fcimb.2025.1535246
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