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Evaluation of Salvia yangii Extract as a Promising Protective Raw Material Applied Topically to the Skin

Summary

Russian Sage (Salvia yangii) extract shows promise as a natural ingredient for skincare products. The study found that the plant contains compounds like rosmarinic acid that provide antioxidant, antimicrobial, and anti-aging benefits. When used at appropriate concentrations, the extract protected skin cells from sun damage and helped inhibit enzymes that break down skin collagen. This research supports the use of S. yangii in developing safer, more effective natural cosmetic products.

Background

Salvia yangii (Russian Sage) is an ornamental plant from the Lamiaceae family with traditional medicinal uses, but limited scientific research on its skin protective properties. The plant contains various bioactive compounds including polyphenolic compounds, diterpenoids, and triterpenoids. There is growing consumer interest in natural cosmetic ingredients with demonstrated efficacy and safety.

Objective

This study aimed to evaluate the chemical composition and skin protective properties of S. yangii extracts obtained through different extraction methods. The research assessed phytochemical composition, antimicrobial activity, antioxidant properties, and skin-relevant biological effects on cell lines.

Results

UAE showed higher polyphenolic content than SFE with identified compounds including rosmarinic acid, hesperidin, and caffeic acid. The extract demonstrated antimicrobial activity (MIC 2-16 mg/mL), antioxidant properties, photoprotective effects against UVB-induced oxidative stress, and inhibition of collagenase, elastase, and tyrosinase. Hydrogel and lotion formulations were successfully developed and characterized.

Conclusion

S. yangii extract shows promising potential as a natural cosmetic ingredient due to its multifaceted skin protective properties including antimicrobial, antioxidant, photoprotective, and anti-aging effects. The extract exhibits concentration-dependent hormetic effects on skin cells with beneficial effects at low concentrations. Future development in the cosmetic industry appears promising based on its chemical profile and demonstrated biological activities.
  • Published in:Molecules,
  • Study Type:In vitro Experimental Study,
  • Source: 10.3390/molecules30173505, PMID: 40942033
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