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Efficacy of Lacticaseibacillus rhamnosus probiotic strains in treating chromate induced dermatitis

Summary

This research shows that a beneficial bacteria called Lacticaseibacillus rhamnosus can help treat skin problems caused by chromate exposure, a common hazard for construction workers and factory employees. The bacteria work by reducing toxic chromate to a less harmful form through a special protein called flavin reductase. When tested on mice with chromate-induced skin damage, the probiotic treatment significantly improved skin healing and reduced inflammation. This suggests these beneficial bacteria could offer a safe, natural treatment for occupational skin conditions caused by heavy metal exposure.

Background

Chromate-induced dermatitis is a significant occupational health concern affecting individuals exposed to chromate compounds in industrial settings. Probiotics have emerged as promising therapeutic agents for various skin conditions due to their capacity to enhance skin barriers and modulate immune responses. This study investigates the potential of chromate-resistant Lacticaseibacillus rhamnosus strains isolated from commercial probiotic products.

Objective

To evaluate the efficacy of Lacticaseibacillus rhamnosus strains in treating chromate-induced dermatitis through assessment of chromate resistance, reduction potential, and therapeutic effects on dermatitis using biochemical, molecular, and in vivo analyses.

Results

Six L. rhamnosus strains (L1-L4, L8, L12) demonstrated high chromate resistance at 500 µg/ml concentrations. L. rhamnosus L1 showed the highest Cr(VI) reduction potential at 56%. Molecular docking simulations revealed strong FMN binding affinity (ΔG = -8.8 kcal/mol for flavin reductase). Histopathological analysis demonstrated that administration of L. rhamnosus strains significantly reduced chromate-induced skin damage and inflammation in mice.

Conclusion

Lacticaseibacillus rhamnosus strains with high chromate resistance and flavin reductase expression demonstrate significant therapeutic potential against chromate-induced dermatitis through chromate reduction and detoxification mechanisms. These probiotic strains represent promising safe and effective interventions for treating heavy metal-induced dermatitis in occupational settings.
  • Published in:Scientific Reports,
  • Study Type:Experimental Research Study,
  • Source: 10.1038/s41598-025-93732-9
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