Disseminated Scytalidium philadelphianum infection in a Belgian Malinois
- Author: mycolabadmin
- 1/11/2025
- View Source
Summary
A Belgian Malinois dog developed a serious fungal infection caused by Scytalidium philadelphianum, a rare mold, that affected the spine and eventually the brain. The infection was diagnosed through imaging, fluid samples, and fungal culture from the dog’s urine and spine tissue. Despite treatment with multiple antifungal medications over seven months, the dog’s condition worsened with seizures and nerve damage, leading to euthanasia. This case marks the first documented instance of this particular fungal species causing widespread disease in animals.
Background
Scytalidium philadelphianum is a dematiaceous mold identified in 2022. Discospondylitis can be caused by bacterial or fungal infection with fungal cases being less common in veterinary medicine. German shepherd dogs and related breeds show predisposition to fungal discospondylitis.
Objective
To report the first case of disseminated Scytalidium philadelphianum infection in veterinary medicine, occurring in a Belgian Malinois with multifocal discospondylitis and progressive neurologic disease.
Results
Scytalidium philadelphianum was identified from both disc aspirates and urine culture. MRI revealed multifocal discospondylitis, osteomyelitis, spondylitis with epidural empyema, and later meningoencephalopathy. Despite aggressive antifungal therapy with amphotericin B, posaconazole, micafungin, and voriconazole, the dog developed seizures and progressive neurologic decline.
Conclusion
Disseminated Scytalidium philadelphianum infection presents a grave prognosis similar to disseminated aspergillosis. The case demonstrates CNS involvement as a complication and highlights the challenges of treating dematiaceous mold infections in veterinary medicine due to lack of standardized susceptibility breakpoints.
- Published in:Medical Mycology Case Reports,
- Study Type:Case Report,
- Source: PMID: 39896754, DOI: 10.1016/j.mmcr.2025.100692