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Differential Immune Activating, Anti-Inflammatory, and Regenerative Properties of the Aqueous, Ethanol, and Solid Fractions of a Medicinal Mushroom Blend

Summary

This research examined how different extracts from a blend of medicinal mushrooms affect the immune system. Scientists found that different components of the mushroom blend had distinct effects on immune function, inflammation control, and tissue repair. The study shows these mushrooms could help support immune health in multiple ways. Impacts on everyday life: • Could lead to better natural supplements for immune system support • May help develop treatments for inflammatory conditions • Suggests potential benefits of including medicinal mushrooms in diet • Could help people recover better from illness or injury • Demonstrates why both water-based and alcohol-based mushroom extracts may be beneficial

Background

Mushrooms have been historically used for their nutritional and medicinal properties in treating infectious disease, gastrointestinal disorders and asthmatic conditions. They contain bioactive compounds including chitin, β-glucans, and other polysaccharides that possess documented immunomodulatory properties through activation of natural killer cells, macrophages, neutrophils and induction of innate immune cytokines.

Objective

To compare three fractions of a medicinal mushroom blend (MMB), MyCommunity, on immune-activation, inflammation-regulation, and induction of biomarkers involved in regenerative functions.

Results

The aqueous and ethanol fractions triggered differential CD69 expression on immune cells, with aqueous fraction activating lymphocytes and ethanol fraction activating monocytes. The solid fraction was the most potent inducer of TNF-α, anti-viral cytokines (IFN-γ, MCP-1, MIP-1α, MIP-1β), growth factors (G-CSF, b-FGF), and anti-inflammatory cytokine IL-1ra.

Conclusion

The aqueous, ethanol, and insoluble compounds within MMB induced differential immune-activating, anti-inflammatory, and regenerative effects. The data suggests that upon consumption, MMB may induce a concerted series of immunomodulatory events based on the differential solubility and bioavailability of active constituents. These responses support both immune-activation and resolution of host defense-induced inflammatory reactions, assisting post-response return to homeostasis.
  • Published in:Journal of Inflammation Research,
  • Study Type:Laboratory Study,
  • Source: 10.2147/JIR.S229446
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