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Dietary Supplementation of Auricularia auricula-judae Polysaccharides Alleviate Nutritional Obesity in Mice via Regulating Inflammatory Response and Lipid Metabolism

Summary

This research investigated how polysaccharides from black wood ear mushrooms (Auricularia auricula-judae) can help combat obesity. The study found that these mushroom compounds could effectively reduce weight gain and improve metabolic health in mice fed high-calorie diets. Impacts on everyday life: – Offers a potential natural supplement option for weight management – Demonstrates the health benefits of incorporating medicinal mushrooms into diet – Provides scientific support for traditional uses of black wood ear mushrooms – Shows promise for developing new anti-obesity treatments – Highlights the importance of exploring natural food resources for health solutions

Background

The incidence of lipid metabolism disorder and obesity caused by high-calorie diets is increasing yearly, becoming an urgent global health problem. According to WHO, global obesity exceeded 650 million people in 2016 and is projected to reach 1.12 billion by 2030. Natural plant extracts have shown therapeutic potential with multiple targets and fewer side effects in preventing and treating obesity.

Objective

To explore the intervention effects of polysaccharides extracted from Auricularia auricula-judae resources in the Qinba Mountain area on nutritional obesity in C57BL/6J mice induced by high fat and high fructose diets (HFFD) and investigate their underlying molecular mechanisms.

Results

AAP supplementation significantly improved mice’s insulin resistance, altered serum lipid metabolites, and slowed down HFFD-induced weight gain. It decreased inflammatory factor levels and alleviated liver histomorphology changes. AAP down-regulated liver adipogenic-related gene expressions, suppressed cholesterol synthesis-related genes, up-regulated fatty acid β-oxidation-related genes, and promoted cholesterol efflux-related gene expressions, thus improving hepatic lipid metabolism homeostasis.

Conclusion

Auricularia auricula-judae polysaccharides from the Qinba Mountain area demonstrated significant anti-obesity effects in mice by regulating inflammatory response and lipid metabolism. The intervention effects were closely related to mitochondrial function. These findings provide scientific basis for further development and utilization of these mushroom resources.
  • Published in:Foods,
  • Study Type:Animal Study,
  • Source: 10.3390/foods11070942
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