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Development and preliminary mechanistic analysis of compound effervescent hepatoprotective granules

Summary

Researchers developed a new health product combining three medicinal plants to protect the liver from injury. The mixture contains effective compounds that reduce liver inflammation, fight harmful oxidative stress, and protect liver cells from damage. Studies in rats showed the product improved liver function and reduced markers of liver damage, suggesting it could be useful for preventing and treating liver injuries caused by drugs, alcohol, or toxins.

Background

Acute liver injury (ALI) from alcohol, drugs, infections, and toxins is a major global health issue. Traditional Chinese medicine components including Ganoderma lucidum polysaccharides, Paeonia lactiflora monoterpenes, glycyrrhizic acid, and flavonoids show hepatoprotective effects, but their combined preparations remain unclear.

Objective

To develop and optimize compound effervescent hepatoprotective granules (CEHG) combining Paeonia lactiflora, Ganoderma lucidum, and Glycyrrhiza glabra, and to validate their hepatoprotective mechanisms through network pharmacology and animal studies.

Results

CEHG contained albiflorin 1.26%, paeoniflorin 5.42%, liquiritin 0.43%, glycyrrhizic acid 1.30%, and ganoderic acid A 0.14%. Network pharmacology revealed involvement of HIF-1, p53, and FoxO pathways. In rats with liver injury, CEHG reduced liver enzymes (AST, ALT, LDH), improved lipid metabolism, decreased inflammatory cytokines, and enhanced antioxidant defense.

Conclusion

The study successfully optimized CEHG extraction and formulation, demonstrating hepatoprotective effects through reduced liver damage, improved liver function, decreased inflammation and oxidative stress, and modulation of apoptosis-related pathways.
  • Published in:Frontiers in Nutrition,
  • Study Type:Experimental Research,
  • Source: PMID: 41170366, DOI: 10.3389/fnut.2025.1639561
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