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Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill

Summary

Agaricus blazei Murill is an edible mushroom that contains many beneficial compounds including polysaccharides, vitamins, and minerals. Research shows it may help boost the immune system, reduce blood sugar levels, protect the liver, fight inflammation, and even have anti-cancer properties. While animal studies show promising results, more human clinical trials are needed to confirm its health benefits and establish proper dosing for therapeutic use.

Background

Agaricus blazei Murrill (AbM) is a medical mushroom with significant commercial and therapeutic potential. It has been used in traditional medicine across multiple countries for various health-promoting functions. However, systematic characterization of its chemical composition and therapeutic mechanisms has been limited.

Objective

This study aims to comprehensively summarize the phytochemical profiles and health-promoting effects of AbM, including antitumor and antidiabetic impacts demonstrated in both in vivo and in vitro studies. The review seeks to characterize the underlying mechanisms of AbM’s therapeutic potential and identify gaps in current clinical research.

Results

AbM contains abundant bioactive substances including polysaccharides (particularly β-glucans), lipids, ergosterol, proteins, vitamins (B1, B2, B9, B12, C, D), and phenolic compounds. Multiple studies demonstrated immunoregulatory, anti-inflammatory, hepatoprotective, antitumor, antidiabetic, and antioxidant functions both in vivo and in vitro. Clinical trials are limited but show promising results, particularly for Crohn’s disease treatment.

Conclusion

AbM exhibits significant health-promoting potential through multiple bioactive compounds and mechanisms. While preclinical evidence is robust, further clinical trials are needed to establish efficacy and safety in human populations. AbM shows promise as a functional food and natural therapeutic agent, though underlying mechanisms require additional clarification.
  • Published in:Current Research in Food Science,
  • Study Type:Critical Review,
  • Source: PMID: 36387602, PMC9661389, DOI: 10.1016/j.crfs.2022.10.029
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