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Corrigendum: Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing

Summary

This research article, published as a correction, examines how chaga mushroom (Inonotus obliquus) may help treat kidney fibrosis in mice. Using advanced genetic sequencing technology that examines individual cells, scientists identified how chaga works by modulating communication between different immune and kidney cells. The findings suggest that chaga could be a promising natural treatment for progressive kidney disease.

Background

Renal fibrosis is a progressive kidney disease that can lead to end-stage renal failure. Inonotus obliquus (chaga) is a traditional Chinese medicine with potential therapeutic properties. This study investigates the molecular mechanisms by which chaga may ameliorate folic acid-induced renal fibrosis.

Objective

To analyze the crosstalk among proximal tubular cells, macrophages, and T cells in chaga-mediated amelioration of folic acid-induced renal fibrosis using single-cell RNA sequencing technology.

Results

The study identified specific crosstalk mechanisms among PT cells, macrophages, and T cells involved in the therapeutic effects of chaga. Single-cell sequencing revealed changes in gene expression and cellular interactions associated with amelioration of renal fibrosis.

Conclusion

Inonotus obliquus ameliorates folic acid-induced renal fibrosis through modulation of immune cell interactions and proximal tubular cell function. The findings suggest chaga’s potential as a therapeutic agent for renal fibrosis treatment.
  • Published in:Frontiers in Pharmacology,
  • Study Type:Corrigendum - Experimental Animal Study,
  • Source: PMID: 40510421; DOI: 10.3389/fphar.2025.1629322
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