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CORRECTION: Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis

Summary

A major research study examining psilocybin’s effectiveness for treating depression has been corrected due to mathematical and data handling errors. The researchers fixed these issues by recalculating statistics and removing duplicate data from their analysis. While the main conclusions remained similar after correction, the authors emphasize this research is still preliminary and should lead to further study before clinical use.

Background

A systematic review and meta-analysis examined the efficacy of psilocybin for treating depression symptoms in adults. The original study was published in May 2024 but subsequently raised methodological concerns.

Objective

To evaluate the efficacy of psilocybin treatment for depression symptoms through systematic review and meta-analysis of randomised controlled trials.

Results

After correction of methodological errors including calculation standardization and removal of duplicate entries, the main findings of the study remained unaltered. Statistical editors confirmed satisfaction with the corrected approach.

Conclusion

The research synthesized is preliminary and does not have immediate clinical implications, requiring further research validation. The correction resolves all matters raised in the expression of concern.
  • Published in:BMJ (British Medical Journal),
  • Study Type:Meta-analysis, Correction,
  • Source: 10.1136/bmj.r111, PMID: 39929528
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