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Complete mitochondrial genome sequence of the Agaricomycetes brown rot fungus Fomitopsis pinicola isolate FBCC1181

Summary

Scientists have sequenced the complete mitochondrial DNA (a small genome within fungal cells) of a wood-rotting mushroom called Fomitopsis pinicola. The mitochondrial genome is 66,500 base pairs long and contains 64 genes typical for this group of fungi. The researchers discovered several special genes called endonucleases within the genome that may help the fungus adapt and change over time.

Background

Fungal mitochondrial genomes are understudied, with only 54 Basidiomycota mitogenomes available in NCBI databases. The genus Fomitopsis has limited genomic resources with only one previously sequenced mitochondrial genome. This study addresses the need for expanded genomic data on wood-decaying basidiomycetes.

Objective

To sequence and characterize the complete mitochondrial genome of Fomitopsis pinicola isolate FBCC1181, a brown rot fungus. The study aimed to determine genome structure, gene content, and identify special genomic features including homing endonucleases.

Results

The mitogenome is 66.5 kbp circular chromosome with 22.6% GC-content, containing 64 predicted genes including 14 conserved protein-coding genes, 2 ribosomal RNA genes, and 28 tRNA genes. Four LAGLIDADG and two putative GIY-YIG endonuclease genes were identified within introns of cox and cob genes.

Conclusion

This is the second mitochondrial genome sequence for Fomitopsis species, providing valuable genomic resources for basidiomycete research. The presence of multiple homing endonucleases in introns suggests genome dynamism typical of fungal mitogenomes.
  • Published in:Microbiology Resource Announcements,
  • Study Type:Genome Sequencing and Annotation,
  • Source: 10.1128/MRA.00503-23, PMID: 37909782
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