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Complete genome sequence analysis of Boeremia exigua, a fungal pathogen causing leaf spot disease of Panax notoginseng

Summary

Scientists have sequenced the complete genome of Boeremia exigua, a fungus that causes leaf spot disease on Panax notoginseng (a valuable traditional Chinese medicinal plant). The study identified important genes related to how the fungus degrades plant cell walls, produces toxins, and causes disease. This genetic information will help researchers better understand how the pathogen works and develop more effective ways to protect the plants from infection.

Background

Panax notoginseng is a highly valued traditional Chinese medicinal plant primarily cultivated in Yunnan Province. In 2022, a novel leaf spot disease was discovered on P. notoginseng leaves, with Boeremia exigua identified as the causal pathogen. However, the genomic basis and pathogenic mechanisms of this pathogen remain poorly understood.

Objective

This study reports the first complete genome sequence of B. exigua, the pathogen causing P. notoginseng leaf spot in China. The research aims to elucidate the genomic features, pathogenic mechanisms, and virulence factors of this fungal pathogen to support development of improved disease management strategies.

Results

The HEI-C genome is approximately 26.35 Mb with 53.14% GC content and 11,701 predicted genes, of which 98.09% showed significant similarity to NCBI nr database entries. Analysis identified 412 CAZy genes involved in plant cell wall degradation, 252 secondary metabolite gene clusters, 47 effector proteins, and 91 virulence-enhancing factors. Phylogenetic analysis confirmed HEI-C as B. exigua with 96.24% genome similarity to reference strains.

Conclusion

The complete genome sequence of B. exigua provides enhanced understanding of its pathogenicity and virulence mechanisms. This genomic data establishes a theoretical foundation for investigating pathogenic mechanisms and developing improved strategies for managing leaf spot disease in P. notoginseng.
  • Published in:BMC Genomics,
  • Study Type:Genomic Analysis,
  • Source: 10.1186/s12864-025-12182-9, PMID: 41174490
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