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Clinical experience of primary subcutaneous mycoses in Shanghai: a retrospective analysis

Summary

Researchers in Shanghai studied 33 patients with deep skin fungal infections that had become increasingly common in the area. They identified 13 different fungal species causing these infections, most commonly Candida parapsilosis, Trichophyton rubrum, and Sporothrix schenckii. Patients were treated with antifungal medications tailored to the specific fungus and its drug sensitivity, with most patients recovering completely, though some experienced relapses, emphasizing the importance of long-term follow-up care.

Background

Primary subcutaneous mycoses are heterogeneous fungal infections caused by pathogenic or opportunistic organisms affecting cutaneous and subcutaneous tissues. Cases have steadily increased in Shanghai, an area where the disease was previously uncommon. This increase is likely due to rising numbers of immunocompromised patients.

Objective

This study aimed to summarize clinical experiences with primary subcutaneous mycoses in Shanghai to optimize their management. The research analyzed clinical features, histopathological findings, etiological characteristics, drug sensitivity results, and therapeutic outcomes.

Results

Isolates included yeast (45.5%), mold (30.3%), and dimorphic fungi (24.2%), with C. parapsilosis (24.2%), T. rubrum (15.2%), and S. schenckii (24.2%) being most common. Thirty-two patients received systemic antifungal treatment based on drug sensitivity results, with 30 achieving complete response, while 3 experienced relapses.

Conclusion

This study highlights considerable diversity among fungal species in primary subcutaneous mycoses and emphasizes complexities in diagnosis and management. Correcting unhealthy lifestyles, boosting immunity, completely removing pathogenic fungi, and avoiding re-exposure can effectively reduce relapse risk.
  • Published in:Frontiers in Cellular and Infection Microbiology,
  • Study Type:Retrospective Analysis,
  • Source: PMID: 40171159, DOI: 10.3389/fcimb.2025.1520608
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