Chemoinformatic Database Building and In Silico Hit-Identification of Potential Multi-Targeting Bioactive Compounds Extracted from Mushroom Species
- Author: mycolabadmin
- 2017-09-19
- View Source
Summary
Background
Mushrooms contain natural compounds that can be used for both nutritive and medicinal properties, including antimicrobial, antiviral, antitumor, anti-allergic, immunomodulation, anti-inflammatory, anti-atherogenic, hypoglycemic, hepatoprotective and antioxidant effects. Scientific interest in natural compounds from fungi is increasing due to their pharmacological/biological activity, though their mechanisms of action are often unknown or not well understood.
Objective
To create a chemical database of compounds extracted from both edible and non-edible mushrooms and virtually screen them against 43 macromolecular targets to provide molecular descriptions of ligand/multi-target recognition. This aims to understand the polypharmacological profile of fungal extracts and suggest strategies for designing new multi-target agents.
Results
Conclusion
- Published in:Molecules,
- Study Type:In Silico Screening Study,
- Source: 10.3390/molecules22091571