Chemical Constituents Identified from Fruit Body of Cordyceps Bassiana and Their Anti-inflammatory Activity
- Author: mycolabadmin
- 2016-08-19
- View Source
Summary
This research identified the key compounds in the medicinal mushroom Cordyceps bassiana that give it anti-inflammatory properties. Scientists isolated eight different compounds and found that one in particular – 1,9-dimethylguanine – was primarily responsible for reducing inflammation. This discovery helps explain why this mushroom has been used traditionally in Asian medicine for various inflammatory conditions.
Impacts on everyday life:
• Could lead to new natural treatments for inflammatory skin conditions like atopic dermatitis
• Validates traditional medicinal uses of this mushroom species
• May help develop new anti-inflammatory supplements or medications
• Provides scientific evidence for using natural mushroom products
• Could benefit people seeking natural alternatives to conventional anti-inflammatory drugs
Background
Cordyceps bassiana is an insect-born mushroom traditionally used in Chinese and Korean medicine as a tonic for longevity, endurance, and vitality. It has demonstrated various biological activities including anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive properties. Recent studies showed its ability to reduce atopic dermatitis symptoms, but its chemical constituents had not been previously analyzed.
Objective
To identify and isolate the chemical constituents from Cordyceps bassiana and evaluate their anti-inflammatory properties to determine the active compounds responsible for its therapeutic effects.
Results
Eight compounds were identified: 1,9-dimethylguanine, adenosine, uridine, nicotinamide, 3-methyluracil, 1,7-dimethylxanthine, nudifloric acid, and mannitol. Compound 1 (1,9-dimethylguanine) showed significant anti-inflammatory activity by blocking NF-κB and AP-1 activation and suppressing mRNA levels of COX-2 and TNF-α.
Conclusion
The study successfully isolated and identified eight compounds from C. bassiana for the first time, with 1,9-dimethylguanine emerging as the major anti-inflammatory component. This compound appears to be a key active ingredient responsible for C. bassiana’s therapeutic effects and warrants further investigation for potential development as an anti-inflammatory and anti-atopic dermatitis treatment.
- Published in:Biomolecules & Therapeutics,
- Study Type:Laboratory Research,
- Source: 10.4062/biomolther.2016.063