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Characteristics of Chrysosporium spp. Pathogens Causing Skin Mycoses in Horses

Summary

Researchers in Kazakhstan discovered two new fungal pathogens affecting horses’ skin for the first time. These fungi, called Chrysosporium kreiselii and Chrysosporium zonatum, cause skin lesions and dandruff in horses. One strain is resistant to most antifungal medications, making it particularly challenging to treat.

Background

Equine skin mycoses are a significant concern in Kazakhstan’s livestock industry. Chrysosporium spp. are emerging keratinophilic pathogens that can degrade keratin in superficial tissues and exhibit thermotolerance, contributing to their pathogenicity.

Objective

To investigate the biological properties and pathogenicity of Chrysosporium strains isolated from equine skin lesions in northern and central Kazakhstan, and to confirm their taxonomic classification through genetic identification.

Results

Two Chrysosporium isolates showed 98.9% identity with C. kreiselii and C. zonatum. C. kreiselii caused pronounced skin lesions, exhibited keratinophilic and keratinolytic properties, and showed resistance to antifungal drugs. C. zonatum caused atypical lesions and was more sensitive to antifungal agents.

Conclusion

Chrysosporium spp. were identified for the first time in horses in Kazakhstan. Both strains exhibited pathogenic properties with keratinophilic capabilities and resistance to fluconazole. Comprehensive retrospective analysis and full pathogenicity characterization of newly identified Chrysosporium pathogens is recommended.
  • Published in:Journal of Fungi (Basel),
  • Study Type:Descriptive Mycological Study,
  • Source: PMID: 40278119
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