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Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

Summary

This research explored how mushroom cultures grown in laboratories could be used to produce valuable medicinal compounds. Scientists studied six species of Ganoderma mushrooms, which have been used in traditional medicine for thousands of years. By growing these mushrooms in controlled laboratory conditions, they found ways to produce beneficial compounds that could be used in medicines and supplements. Impacts on everyday life: • Provides a sustainable way to produce natural medicines without harvesting wild mushrooms • Could lead to new treatments for conditions like Alzheimer’s disease and diabetes • May result in new natural ingredients for skincare products and supplements • Offers potential alternatives to synthetic pharmaceutical compounds • Could make traditional Asian medicine more accessible globally

Background

Species in the genus Ganoderma are considered important natural sources of compounds with medicinal properties, with therapeutic effects known for thousands of years. They are most popular in Asia, especially in Traditional Chinese Medicine (TCM), and are also used traditionally in some West African countries for treating skin diseases, hypertension, and digestive disorders. Scientific research has confirmed their broad-spectrum effects including antitumor, immunomodulatory, antioxidant, anti-inflammatory, antiallergic, neuroprotective, hepatoprotective, hypoglycemic, hypotensive, antimicrobial, antiviral, and antimalarial properties.

Objective

The study aimed to assess the biosynthetic potential of mycelial cultures of six Ganoderma species: G. adspersum, G.applanatum, G. carnosum, G. lucidum, G. pfeifferi, and G. resinaceum. The research focused on evaluating the bioactivity of extracts from mycelial cultures as sources of compounds with health promoting properties.

Results

The total content of phenolic acids ranged from 5.8 to 114.07 mg/100g dry weight, with G. pfeifferi showing the highest content. Indole compounds ranged from 3.03 to 11.56 mg/100g d.w., highest in G. lucidum. Ergosterol content varied from 28.15 to 74.78 mg/100g d.w., highest in G. adspersum. Kojic acid was found in G. applanatum and G. lucidum extracts. The extracts showed significant antioxidant activity and varying levels of enzyme inhibition properties.

Conclusion

The biomass of the investigated Ganoderma species can serve as an alternative to natural or cultivated material as a valuable raw material for the pharmaceutical or cosmetic industry. The production can be controlled and stimulated through mycelial cultures, offering a promising source for developing new dietary supplements or pharmaceutical preparations.
  • Published in:Molecules,
  • Study Type:Laboratory Research,
  • Source: 10.3390/molecules27010275
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