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Bioactive Steroids Bearing Oxirane Ring

Summary

This research reviews special types of steroids that contain oxirane rings, which are highly reactive chemical structures found in marine organisms, fungi, and plants. These compounds have shown promise in treating various diseases including cancer, inflammation, and high cholesterol. Scientists used computer software to predict and analyze the biological activities of over 150 different epoxy steroids, categorizing them by the position of their oxirane ring. The findings suggest these natural compounds could be valuable for developing new medicines and understanding how chemicals interact with our bodies.

Background

Steroids and isoprenoid lipids containing oxirane rings are natural compounds derived from fungi, fungal endophytes, plants, algae, and marine invertebrates. The oxirane ring is a highly reactive three-membered epoxide ring that can undergo various chemical reactions and biological interactions.

Objective

This review explores the biological activity and structural diversity of steroids bearing oxirane rings, with particular focus on their antineoplastic, anti-inflammatory, and other pharmacological properties. The review systematically categorizes these compounds based on epoxy group positioning and evaluates their potential therapeutic applications.

Results

Six major groups of epoxy steroids were identified based on epoxy group position: 4,5-epoxy, 5,6-epoxy, 7,8- and 8,9-epoxy, 9,11- and 11,12-epoxy, 17,20-epoxy and 24,25-epoxy, and miscellaneous epoxy steroids. These compounds exhibited diverse biological activities including antineoplastic, anti-inflammatory, antifungal, antibacterial, and antiviral properties with varying confidence levels above 0.6-0.9 probability.

Conclusion

Steroids bearing oxirane rings demonstrate significant bioactive potential across multiple pharmacological applications. Their structural diversity and multifaceted biological activities make them valuable candidates for drug discovery and development in medicine and pharmacology.
  • Published in:Biomedicines,
  • Study Type:Review,
  • Source: PMID: 37626733, DOI: 10.3390/biomedicines11082237
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