MYCOLab Ai Logo - gold and army green

Bio-prospective Potential of Pleurotus djamor and Pleurotus florida Mycelial Extracts Towards Gram Positive and Gram Negative Microbial Pathogens Causing Infectious Disease

Summary

This research explores how extracts from two types of oyster mushrooms could potentially fight bacterial infections and cancer cells. The study found that these mushroom extracts contain natural compounds that can kill harmful bacteria and slow the growth of breast cancer cells in laboratory tests. This discovery is particularly important as we face increasing antibiotic resistance worldwide. Impacts on everyday life: • Could lead to new natural antibiotics to fight infections • May help develop alternative cancer treatments • Demonstrates the medical potential of common edible mushrooms • Offers a sustainable source of new medicines • Highlights the importance of preserving fungal biodiversity

Background

The increasing resistance to commonly used antibiotics in human infections, primarily due to overuse, has created a need for novel and innovative treatments. This study focuses on examining the potential of mushroom mycelial extracts as an alternative antimicrobial source.

Objective

To evaluate the phytochemical characteristics, antibacterial activity, and cytotoxicity of MCF7 cells using mycelial extracts from two Pleurotus species (P. djamor and P. florida).

Results

Both P. djamor and P. florida mycelial extracts showed significant antimicrobial effects against tested bacterial and fungal pathogens. The dichloromethane extracts tested positive for various phytochemicals, including flavonoids, anthroquinone, and terpenoid compounds. In cytotoxicity tests, both species demonstrated dose-dependent antiproliferative activity against MCF7 cells, with P. florida showing 64.47% inhibition and P. djamor showing 55.72% inhibition at 125 μg/mL.

Conclusion

The study successfully identified key bioactive components in the DCM extracts from P. djamor and P. florida mycelia, demonstrating their potential biological activity and antimicrobial properties.
  • Published in:Journal of Infection and Public Health,
  • Study Type:Laboratory Research,
  • Source: 10.1016/j.jiph.2021.10.012
Scroll to Top