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Auricularia auricula polysaccharides attenuate obesity in mice through gut commensal Papillibacter cinnamivorans

Summary

This research discovered that compounds from the edible mushroom Auricularia auricula can help prevent obesity by promoting beneficial gut bacteria. The study found that polysaccharides from this mushroom specifically increase a helpful bacteria called Papillibacter cinnamivorans, which helps reduce weight gain and improve metabolism. Impacts on everyday life: • Provides evidence that eating certain mushrooms may help with weight management • Identifies a new probiotic bacteria that could be developed into weight loss supplements • Demonstrates how dietary choices can positively influence gut bacteria • Offers potential new natural approaches for treating obesity • Suggests mushroom extracts could be developed into prebiotic supplements

Background

Obesity is a major chronic disease that impacts health and quality of life in modern society. The gut microbiota plays an important role in obesity development. Auricularia auricula is a traditional edible and medicinal fungus with various bioactive compounds, particularly polysaccharides, but their exact mechanisms in obesity prevention remain unclear.

Objective

To investigate the effects of Auricularia auricula polysaccharides (AAP) on obesity and related metabolic endpoints, and determine the mechanistic role of the gut microbiota, particularly Papillibacter cinnamivorans, in mediating these effects.

Results

AAP treatment prevented HFD-induced weight gain, reduced fat deposits, and improved glucose tolerance. These effects were dependent on gut microbiota and transferable via fecal transplantation. AAP selectively enhanced P. cinnamivorans abundance, which was reduced in HFD mice. Direct administration of P. cinnamivorans attenuated obesity by regulating intestinal lipid absorption and hepatic thermogenesis through reducing inflammatory response and gut permeability via JAK-STAT signaling.

Conclusion

AAP prevents diet-induced obesity and metabolic disorders by modulating the gut microbiota, specifically through enhancing P. cinnamivorans. This study identifies both AAP and P. cinnamivorans as potential therapeutic agents for treating obesity, functioning as novel pre- and probiotics respectively.
  • Published in:Journal of Advanced Research,
  • Study Type:Experimental Animal Study,
  • Source: 10.1016/j.jare.2023.08.003
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