Assessment of Heavy Metals in Mexican Dietary Supplements Using Total X-Ray Fluorescence Spectrometry and Health Risk Evaluation

Summary

Mexican dietary supplements commonly contain toxic heavy metals like lead, arsenic, and chromium. While individual metal levels in most supplements appeared safe when consumed alone, the cumulative exposure from multiple metals could increase cancer risk over a lifetime. The study found that some popular supplements, particularly those marketed for weight loss and blood detoxification, contained concerning metal levels, especially seaweed-based products and animal-origin supplements. Better regulation and labeling of dietary supplements in Mexico is urgently needed to protect consumers from long-term health risks.

Background

Dietary supplements are increasingly consumed by the Mexican population, with a market value near $535.96 million annually. However, heavy metal contamination in dietary supplements poses significant public health risks due to contamination throughout the supply chain from agricultural, manufacturing, and distribution sources.

Objective

This study aimed to analyze levels of lead, arsenic, and chromium in 45 Mexican dietary supplements using Total X-ray Fluorescence Spectrometry (TXRF) and to perform health risk assessment using Target Hazard Quotient (THQ), Hazard Index (HI), and Cumulative Cancer Risk (CCR) calculations.

Results

Mean metal concentrations were 1.99±0.13 mg/kg for Pb, 26.88±0.23 mg/kg for Cr, and 2.39±0.11 mg/kg for As. Eighty percent of supplements showed low lead EDIs, while 100% had chromium EDIs below regulatory limits. However, some animal-origin supplements exceeded arsenic reference values, and several supplements showed HI values greater than 1, indicating potential cumulative health risk.

Conclusion

While most individual metal EDIs comply with regulatory standards, cumulative cancer risk values exceeded acceptable thresholds for all supplements analyzed, indicating a probability of cancer development from lifetime metal exposure. Effective communication of these risks and implementation of stricter Mexican regulatory standards for heavy metals in dietary supplements is crucial for public health protection.
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