Antiproliferative Protein from the Culture Supernatant of Lentinula edodes C91-3 Mycelia
- Author: mycolabadmin
- 2014-06-11
- View Source
Summary
Scientists have discovered a new protein from shiitake mushroom that can fight cancer cells without harming normal cells. This research shows how natural compounds from mushrooms could potentially be used to develop safer cancer treatments.
Impacts on everyday life:
• Provides new hope for natural cancer treatments with fewer side effects
• Demonstrates the medicinal value of common edible mushrooms
• Shows potential for developing new pharmaceutical products from natural sources
• Supports the growing field of mushroom-based medicine
• Highlights the importance of fungi in human health applications
Background
Lentinula edodes (shiitake mushroom) has been studied for its potential antitumor properties. Research has focused on identifying and characterizing bioactive compounds from its mycelia that could have therapeutic applications.
Objective
To purify, isolate and characterize a novel protein (LFP91-3A2) from Lentinula edodes C91-3 liquid mycelial culture supernatant and evaluate its antitumor effects.
Results
A novel 26 kDa protein was isolated and characterized. The protein demonstrated significant tumor cell growth reduction in a dose-dependent manner (5-15 μg/mL) while showing no toxic effects on normal chick embryo fibroblasts. The antiproliferative mechanism was found to work through inducing cell apoptosis.
Conclusion
LFP91-3A2 is a novel protein from Lentinula edodes that exhibits tumor-suppressive activity by inducing apoptosis in tumor cells without toxicity to normal cells. This makes it a promising candidate for natural product-based clinical cancer treatments.
- Published in:Journal of Agricultural and Food Chemistry,
- Study Type:Laboratory Research,
- Source: 10.1021/jf500316f