Antioxidant and Immunomodulatory Activities of Polysaccharides from Fermented Wheat Products of Grifola frondosa: In Vitro Methods
- Author: mycolabadmin
- 2023-08-09
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Summary
This research investigated how fermenting wheat with medicinal mushrooms (Grifola frondosa) could create a healthy functional food product. The scientists found that the fermented wheat contained beneficial compounds that could boost immune function and act as antioxidants. This has important implications for everyday life:
• The fermented wheat product could be easily incorporated into regular diets as a health-promoting food
• It provides a cost-effective way to get the health benefits of medicinal mushrooms
• The production method is suitable for large-scale manufacturing of functional foods
• It offers a new way to enhance the nutritional value of common wheat-based foods
• The antioxidant properties could help protect cells from damage and support overall health
Background
Grifola frondosa is a basidiomycete fungus known for its medicinal properties, including improving energy levels, strengthening the immune system, and supporting respiratory and liver health. While G. frondosa’s health benefits are well-documented, there is limited understanding of the antioxidant and immunomodulatory properties of different varieties when fermented with wheat grains.
Objective
To explore the potential of G. frondosa-fermented wheat flour as a functional food by analyzing the antioxidant and immunomodulatory properties of polysaccharides extracted from three different varieties of G. frondosa (GFA, GFB, and GFC) fermented with wheat grains.
Results
The study found significant variations between the three G. frondosa varieties. Glucose was the predominant monosaccharide, followed by galactose and mannose. Each variety showed different molecular weight distributions. At 1.25 mg/mL concentration, GFA-wheat and GFB-wheat polysaccharides increased DPPH scavenging ability by 76.8% and 58.7% respectively. The polysaccharides showed no toxicity and enhanced NO, IL-6, and TNF-α production in RAW 246.7 macrophages. GFB-wheat polysaccharides demonstrated particularly strong immunomodulatory properties at 5μg/mL concentration.
Conclusion
The combination of G. frondosa and wheat in fermented products shows potential as a functional food with immune-modulatory effects suitable for daily diet integration. The polysaccharides from G. frondosa-fermented wheat flour promoted macrophage proliferation and demonstrated significant immune-modulatory effects through NO, TNF-α, and IL-6 induction. This approach simplifies production and lowers costs compared to pure G. frondosa polysaccharides, making it feasible for large-scale preparation.
- Published in:International Journal of Food Science,
- Study Type:In Vitro Study,
- Source: 10.1155/2023/3820276