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Antioxidant and Anti-inflammatory Properties of an Extract Rich in Polysaccharides of the Mushroom Polyporus dermoporus

Summary

This research examined the medicinal properties of compounds extracted from the mushroom Polyporus dermoporus. The study found that the mushroom contains special sugar molecules (polysaccharides) that have powerful antioxidant and anti-inflammatory effects without being toxic to normal cells. This discovery could lead to new natural treatments for various inflammatory conditions and diseases caused by oxidative stress. Impacts on everyday life: • Could provide a natural alternative to synthetic anti-inflammatory medications • May help develop new supplements for preventing age-related diseases • Offers potential new treatments for inflammatory conditions with fewer side effects • Demonstrates the value of mushrooms as sources of beneficial compounds for human health • Could lead to development of new natural antioxidant supplements

Background

Fungal polysaccharides have received considerable attention due to their potential therapeutic uses in various industries including cosmetics, pharmaceuticals and food. Many basidiomycete mushrooms contain biologically active polysaccharides in fruit bodies, culture mycelium and culture broth. These compounds have shown antioxidant and anti-inflammatory properties that could help prevent diseases caused by oxidative stress and inflammation.

Objective

To analyze the chemical features of a β-glucan-protein complex from Polyporus dermoporus and evaluate its antioxidant, anti-inflammatory and cytotoxic activities.

Results

The extract contained 64.8% carbohydrates and 10% proteins, with β-glucan confirmed by NMR analysis. It showed strong antioxidant activity, inhibiting lipid peroxidation (42.9%) and superoxide radicals (83.3%) at 67 μg/mL, and hydroxyl radicals (96%) at 267 μg/mL. The extract demonstrated significant anti-inflammatory effects, reducing polymorphonuclear cells by 92.5% and nitric oxide by 68.7% at 30 mg/kg in the pleurisy model. It reduced croton oil-induced ear edema by 65.6% at 30 mg/kg. No cytotoxic effects were observed.

Conclusion

The polysaccharide extract from P. dermoporus possesses potent antioxidant properties and significant anti-inflammatory activity without cytotoxic effects. The glucans appear to inhibit diapedesis after cell migration to injury sites. These findings suggest potential therapeutic applications for this mushroom extract in treating inflammatory conditions and oxidative stress-related diseases.
  • Published in:Antioxidants (Basel),
  • Study Type:Experimental Study,
  • Source: 10.3390/antiox3040730
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