Antioxidant Activity of Phellinus igniarius Fermentation Mycelia Contributions of Different Solvent Extractions and their Inhibitory Effect on α-Amylase
- Author: mycolabadmin
- 2023-12-26
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Summary
This research explores how fermented mushroom extracts could help manage diabetes through natural means. Scientists found that certain compounds from the Phellinus igniarius mushroom can help control blood sugar levels by inhibiting an enzyme that breaks down carbohydrates. The study demonstrates a promising natural alternative for diabetes management.
Impacts on everyday life:
• Provides a potential natural supplement option for people managing diabetes
• Offers a new way to produce beneficial mushroom compounds through fermentation rather than wild harvesting
• Demonstrates how traditional medicines can be scientifically validated for modern healthcare
• Could lead to new food additives that help control blood sugar levels
• Shows promise for developing safer, natural alternatives to synthetic diabetes medications
Background
Phellinus species have historically been used as traditional medicines to treat various diseases due to their antioxidant, antitumor, and antidiabetic activities. Type 2 diabetes mellitus (T2DM) is expected to affect 300 million people by 2025, making the control of postprandial blood glucose levels crucial in treatment. Medicinal mushrooms contain natural bioactive compounds that can act as hypoglycemic and antidiabetic agents without harmful side effects.
Objective
To evaluate and compare the polysaccharide contents, antioxidant properties, and α-amylase inhibitory activities of four Phellinus strains, and to analyze the characteristics and bioactivities of polysaccharides extracted using different solvents from the most promising strain.
Results
P. igniarius QB72 showed higher polysaccharide production, stronger DPPH radical scavenging, and α-amylase inhibitory activity compared to other strains. Hot water extract polysaccharides exhibited the highest DPPH radical scavenging and strong inhibitory activity against α-amylase with an IC50 value of 6.84 ± 0.37 mg/mL. The carbohydrate content of A1 (approximately 17457 Da) was approximately 88.28%. After DEAE water elution, the α-amylase inhibitory activity IC50 decreased to 3.178 ± 0.187 mg/mL.
Conclusion
P. igniarius QB72 hot-water extracts of partially purified polysaccharides demonstrate significant potential as α-amylase inhibitors suitable for food and medication-assisted additives. The research validates the effectiveness of fermentation mycelia as a source of bioactive polysaccharides with antidiabetic properties.
- Published in:Heliyon,
- Study Type:Laboratory Research,
- Source: 10.1016/j.heliyon.2023.e23370