MYCOLab Ai Logo - gold and army green

Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial

Summary

This study tested whether Ganoderma lucidum, a medicinal mushroom used in traditional Asian medicine, could treat denture stomatitis as effectively as the standard treatment clotrimazole. Both treatments reduced pain and improved symptoms equally well over two weeks. The results suggest that Ganoderma lucidum could be a useful alternative for patients who don’t respond well to standard antifungal drugs.

Background

Candida-associated denture stomatitis is the most common form of oral candidiasis with a prevalence rate of 11%-67%. While topical agents like clotrimazole are standard treatments, drug resistance is common in some patients. Ganoderma lucidum has demonstrated antifungal, antiviral, and immunomodulatory properties in traditional Asian medicine.

Objective

This study aimed to compare the antifungal efficacy of Ganoderma lucidum extract gel with clotrimazole gel for the clinical treatment of denture stomatitis types I and II.

Results

Complete recovery at day 7 was higher in the G. lucidum group (28%) compared to clotrimazole (16%), but this difference was not statistically significant (P=0.592). Not wearing dentures overnight significantly increased odds of recovery by 6.56 times. Both groups showed significant pain reduction over the 14-day period (P<0.001).

Conclusion

No significant difference existed between the antifungal efficacy of G. lucidum and clotrimazole for clinical treatment of denture stomatitis. Ganoderma may be regarded as an alternative treatment option, especially in azole-resistant patients, though further clinical studies are required.
  • Published in:Front Dent (Frontiers in Dentistry),
  • Study Type:Randomized Clinical Trial,
  • Source: PMID: 39906373, DOI: 10.18502/fid.v21i45.17178
Scroll to Top