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Anti-Inflammatory Effects of Solanum tuberosum L. Polysaccharide and Its Limited Gene Expression Profile

Summary

Researchers studied a natural compound from potatoes called STP that reduces inflammation in the body. Using laboratory cells and animal models, they found that STP works similarly to the common pain reliever ibuprofen by reducing inflammatory chemicals and activating the body’s protective defense systems. This discovery suggests that potato-based polysaccharides could be developed into new treatments for inflammatory diseases and conditions related to oxidative stress.

Background

Polysaccharides from natural sources demonstrate significant immunomodulatory properties by regulating immune cell functions and inflammatory responses through receptor interactions. Previous studies showed potent anti-inflammatory activity of Solanum tuberosum L. polysaccharide (STP) in peptic ulcer models, but the molecular mechanisms underlying this activity remain incompletely understood.

Objective

To investigate the molecular mechanisms of STP’s anti-inflammatory effects and explore its therapeutic potential in different inflammatory models using LPS-induced inflammation in THP-1 macrophage-like cells, rat pocket granuloma, and carrageenan-induced oedema models.

Results

STP significantly reduced pro-inflammatory cytokine expression (IL6, TNF, IL1B) while increasing anti-inflammatory IL10 expression in a dose-dependent manner. In vivo studies demonstrated comparable anti-exudative effects to ibuprofen, with STP also activating cellular defense mechanisms through NRF2 upregulation and modulation of apoptosis-regulating genes (BCL2, BAX).

Conclusion

STP exhibits multifactorial anti-inflammatory activity through suppression of pro-inflammatory cytokines, activation of antioxidant responses, and modulation of cellular survival mechanisms, positioning it as a promising therapeutic candidate for inflammatory diseases comparable to standard NSAIDs.
  • Published in:International Journal of Molecular Sciences,
  • Study Type:Experimental Study (In Vitro and In Vivo),
  • Source: PMID: 40565025, DOI: 10.3390/ijms26125562
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