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Anti-Hyperlipidemia and Gut Microbiota Community Regulation Effects of Selenium-Rich Cordyceps militaris Polysaccharides on High-Fat Diet-Fed Mice

Summary

This research investigated how selenium-enriched mushroom compounds could help combat obesity and related health issues. Scientists found that giving mice a high dose of selenium-rich mushroom extract helped reduce fat accumulation, lower cholesterol levels, and improve gut bacteria balance. This has important implications for human health: • Could provide a natural alternative to current obesity medications with fewer side effects • Offers potential new functional food ingredients for managing weight and cholesterol • Demonstrates how enriching mushrooms with selenium can enhance their health benefits • Shows promise for developing safer, natural treatments for metabolic disorders • Highlights the connection between gut bacteria and metabolic health

Background

Obesity and associated metabolic disorders are major public health issues that increase risks of diseases like type-2 diabetes, fatty liver diseases, cardiovascular diseases, and cancers. Current medications have varied efficacy and side effects. Polysaccharides from natural sources like Cordyceps militaris show promise as therapeutic agents, particularly when enriched with selenium.

Objective

To investigate the anti-obesity and gut microbiota modulatory effects of crude polysaccharides separated from selenium-rich Cordyceps militaris (SeCMP) on high-fat diet (HFD)-fed C57BL/6J mice model.

Results

High-dose SeCMP (200 mg/kg) significantly reduced serum triglyceride and LDL-C levels by 51.5% and 44.1% respectively compared to HFD-fed mice. It also decreased inflammatory markers, improved anti-inflammatory gene expression, promoted satiety and thermogenesis. SeCMP-200 significantly altered gut bacteria composition, decreasing obesity-associated bacteria like Dorea, Lactobacillus, Clostridium, and Ruminococcus while increasing beneficial bacteria like Akkermansia.

Conclusion

High-dose selenium-rich C. militaris polysaccharides (SeCMP-200) effectively prevented HFD-induced dyslipidemia and gut microbiota dysbiosis in mice. The treatment ameliorated fat accumulation, inflammation, and metabolic disorders, suggesting potential use as a therapeutic agent for lipid metabolic disorders.
  • Published in:Foods,
  • Study Type:Animal Study,
  • Source: 10.3390/foods10102252
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