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Anti-glycated and Antiradical Activities in vitro of Polysaccharides from Ganoderma capense

Summary

This research examined compounds called polysaccharides from the medicinal mushroom Ganoderma capense and their potential health benefits. The study found these compounds could help prevent protein damage caused by high blood sugar and protect cells from harmful free radicals. Impact on everyday life: • Could lead to new natural supplements for managing diabetes and age-related conditions • Provides scientific support for traditional use of medicinal mushrooms in Asian healthcare • Offers potential natural alternatives to synthetic antioxidant supplements • May help develop new anti-aging products and treatments • Demonstrates the ongoing value of studying traditional medicines using modern scientific methods

Background

Ganoderma capense is a medicinal mushroom widely used in Asia for health promotion and treatment of chronic diseases like diabetes and aging. It is rich in polysaccharides. Glycation plays a significant role in diabetic complications and aging, while oxidative stress is involved in many diseases. Finding natural compounds with anti-glycation and antioxidant properties is therefore of great interest.

Objective

To isolate polysaccharides from G. capense and evaluate their anti-glycated and antiradical activities in vitro.

Results

The four crude polysaccharides showed concentration-dependent scavenging abilities on DPPH and hydroxyl radicals. GC70 demonstrated good potential for inhibiting advanced glycation end product formation, with both time- and dose-dependent effects observed. GC90 and GCB showed strong DPPH radical scavenging at high concentrations, with GC90 reaching 99.4% scavenging rate at 8mg/ml. For hydroxyl radical scavenging, GC70 exhibited the strongest activity at concentrations above 5mg/ml.

Conclusion

Among the four isolated polysaccharides, GC70 showed the most promising anti-glycation activity and strong antiradical effects against hydroxyl radicals. The polysaccharides demonstrated concentration-dependent antioxidant properties, with different fractions showing varying levels of effectiveness against different types of free radicals.
  • Published in:Pharmacognosy Magazine,
  • Study Type:In Vitro Study,
  • Source: 10.4103/0973-1296.108132
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