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Anti-Angiotensin Converting Enzyme (ACE) Proteins from Mycelia of Ganoderma lucidum (Curtis) P. Karst

Summary

This research discovered that proteins from the mycelia (root-like structures) of the medicinal mushroom Ganoderma lucidum can help lower blood pressure naturally. The scientists identified four different proteins that work in various ways to reduce blood pressure, potentially offering a safer alternative to conventional blood pressure medications. Impacts on everyday life: • Provides a natural option for people seeking alternatives to synthetic blood pressure medications • Offers potential for new supplements derived from edible mushrooms with fewer side effects • Demonstrates the value of traditional medicine in modern healthcare • Shows promise for more affordable blood pressure treatment options • Highlights the importance of mushrooms as functional foods for health maintenance

Background

Hypertension is a major global health problem affecting approximately 40% of adults aged 25 and above worldwide. It is a significant contributor to cardiovascular disease. While synthetic ACE inhibitors are available for treatment, they can cause side effects like skin rash, taste disturbance, and cough. Natural ACE inhibitory peptides from food proteins have emerged as a safer alternative for blood pressure management.

Objective

This study aimed to isolate and characterize peptides/proteins with promising anti-ACE activity from the mycelia of Ganoderma lucidum, investigating their potential as natural antihypertensive compounds.

Results

The mycelia crude water extract showed ACE inhibition with IC50 value of 1.134 mg/mL. Following protein fractionation and HPLC purification, several protein fractions demonstrated potent ACE inhibitory activity with IC50 values less than 200 μg/mL. Four antihypertensive-related proteins were identified: cystathionine beta synthase-like protein, DEAD/DEAH box helicase-like protein, paxillin-like protein, and alpha/beta hydrolase-like protein.

Conclusion

The study suggests that G. lucidum mycelia has high potential in lowering blood pressure due to the presence of several antihypertensive-related proteins that work through different mechanisms. These proteins from edible mushrooms may serve as safer alternatives to conventional antihypertensive drugs.
  • Published in:BMC Complementary and Alternative Medicine,
  • Study Type:Laboratory Research,
  • Source: 10.1186/1472-6882-13-256
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