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Analysis of Antioxidant and Anti-inflammatory Activities of Solvent Fractions from Rhynchosia nulubilis Cultivated with Ganoderma lucidum Mycelium

Summary

This research examined the health benefits of combining black beans with medicinal mushroom compounds. Scientists found that specific extracts from this combination had powerful antioxidant and anti-inflammatory properties that could benefit human health. The study is particularly relevant for everyday life in these ways: • Could lead to development of natural food supplements to fight inflammation and oxidative stress • Provides a scientific basis for traditional Asian medicine practices using mushrooms • Demonstrates how combining common foods can enhance their health benefits • Offers potential natural alternatives to synthetic antioxidant supplements • May help in developing new functional foods for healthy aging

Background

The worldwide increase in life expectancy and aging populations has increased interest in healthy aging and natural antioxidant/anti-inflammatory substances. While artificial antioxidants exist, they can increase cancer risk through bodily accumulation. Similarly, conventional anti-inflammatory drugs can have side effects. Natural alternatives that inhibit inflammation mediators are being actively studied.

Objective

To analyze the antioxidant and anti-inflammatory activities of different solvent fractions from Rhynchosia nulubilis cultivated with Ganoderma lucidum mycelium (RNGM) and determine their total polyphenol, flavonoid, isoflavone and β-glucan content.

Results

The ethyl acetate fraction showed the highest DPPH scavenging activity (76.60% at 800 μg/mL), ABTS radical scavenging (86.61% at 1,000 μg/mL), and FRAP values. It also strongly inhibited NO production and contained the highest amounts of total polyphenols (65.33 mg GAE/g), flavonoids (18.50 mg QE/g), and β-glucan (13.02%). After hydrolysis, the ethyl acetate fraction contained the highest levels of isoflavones daidzein (27.60 mg/g) and genistein (39.38 mg/g).

Conclusion

The ethyl acetate fraction of Rhynchosia nulubilis cultivated with Ganoderma lucidum mycelium demonstrates strong potential as a natural source of antioxidant and immunomodulatory compounds for nutritional and pharmaceutical applications.
  • Published in:Preventive Nutrition and Food Science,
  • Study Type:Laboratory Research,
  • Source: 10.3746/pnf.2017.22.4.365
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