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Alcohol Extracts from Ganoderma Lucidum Delay the Progress of Alzheimer’s Disease by Regulating DNA Methylation in Rodents

Summary

This research investigated how extracts from the medicinal mushroom Ganoderma lucidum could help slow down Alzheimer’s disease progression by affecting DNA methylation, which is an important process that regulates genes. The study found that alcohol-based extracts from this mushroom could improve memory and learning while protecting brain cells from damage. Impacts on everyday life: • Provides evidence for the traditional use of Ganoderma lucidum as a natural remedy for cognitive health • Suggests a potential natural supplement option for preventing age-related cognitive decline • Demonstrates how traditional medicines can be scientifically validated for modern therapeutic use • Opens new possibilities for developing natural treatments for Alzheimer’s disease • Highlights the importance of dietary supplements in maintaining brain health

Background

DNA methylation changes are involved in age-related diseases including Alzheimer’s disease (AD). Modulation of these methylation changes may be an effective strategy to delay AD progression. Ganoderma lucidum is a medicinal mushroom traditionally used in Asia that has shown anti-aging and antioxidant properties.

Objective

To screen the main active extracts from Ganoderma lucidum for anti-aging properties and evaluate their effects on DNA methylation in AD model rodents.

Results

Alcohol extracts of G. lucidum were identified as the main active anti-aging components. Treatment with these extracts led to up-regulation of methylation regulators in brain tissues. The extracts improved learning and memory function, reduced neuronal apoptosis and brain atrophy, and decreased expression of the AD marker Aβ1-42. Molecular analysis revealed regulation of multiple methylation-related pathways.

Conclusion

Alcohol extracts from G. lucidum, particularly ganoderic acid and lucidone A components, can delay AD progression through regulation of DNA methylation pathways. The extracts demonstrate therapeutic potential for treating AD through epigenetic mechanisms.
  • Published in:Frontiers in Pharmacology,
  • Study Type:Experimental Animal Study,
  • Source: 10.3389/fphar.2019.00272
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