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A new highly digestible prescription diet containing Bacillus velezensis DSM 15544, fructo-oligosaccharides, plasma immunoglobulin, yeast and sepiolite for the management of acute diarrhea in dogs—a randomized double-blinded, controlled trial

Summary

Dogs with sudden diarrhea often improve on their own, but a new specialized diet was tested to speed up recovery. The diet contained beneficial bacteria (Bacillus velezensis), fiber that feeds good bacteria (fructo-oligosaccharides), protective proteins from pork plasma, yeast, and a mineral that helps firm up stools. Dogs eating this special diet recovered in about 3-4 days compared to 6 days on a regular digestive diet, with 98% improving within a week versus only 66% with the control diet.

Background

Acute diarrhea is one of the most common reasons for veterinary consultations in dogs in Western countries, affecting approximately 10-20% of dogs visiting primary veterinary practices. Current treatment approaches are moving away from antimicrobials toward alternative therapies aimed at restoring gut microbiota through biotics and dietary modifications.

Objective

To determine if a newly formulated highly digestible diet containing Bacillus velezensis DSM 15544, fructo-oligosaccharides, animal plasma protein, dried whole yeast and sepiolite would reduce the time to achieve normal fecal consistency in dogs with acute diarrhea compared to a highly digestible control diet.

Results

Dogs fed Diet B (n=56) had significantly faster recovery with normal fecal consistency achieved in 3.6±0.9 days versus 5.9±0.9 days for Diet A (n=55). Diet B showed 98% of dogs recovered within 8 days compared to 66% with Diet A, with 1.6 times greater chance of recovery. Dysbiosis index improved with Diet B (−1±3 vs 0.65±3 for Diet A) and owner satisfaction scores were significantly higher.

Conclusion

Diet B containing Bacillus velezensis DSM 15544, fructo-oligosaccharides, plasma immunoglobulin, yeast and sepiolite resulted in faster clinical resolution, improved fecal consistency, frequency and odor, and reduced dysbiosis incidence compared to the control diet, making it a superior dietary approach for managing mild acute diarrhea in dogs.
  • Published in:Frontiers in Veterinary Science,
  • Study Type:Clinical Trial,
  • Source: PMID: 41473114, DOI: 10.3389/fvets.2025.1665730
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