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A case of corneal infection with Clonostachys rosea

Summary

A 53-year-old patient developed a corneal infection caused by a fungus called Clonostachys rosea, likely from an eye injury. This is the first reported case of this particular fungus infecting the cornea. The infection was successfully treated with antifungal eye drops and oral medications, with the ulcer healing into a scar within one month.

Background

Fungal keratitis poses a significant threat to vision, with Fusarium, Aspergillus, and Candida being the most prevalent causative strains. No cases of corneal infection attributed to Clonostachys rosea have been previously reported. This case describes the first reported instance of corneal infection caused by this fungus.

Objective

To report and describe a case of corneal infection caused by Clonostachys rosea, outline its development and treatment, and enhance clinical understanding and management of similar infections.

Results

Corneal scrape culture confirmed fungal growth with branch-separated mycelium. Sequencing identified the pathogen as Clonostachys rosea (GenBank No. MN889471.1, 100% similarity). Treatment with natamycin, fluconazole eye drops, and oral terbinafine resulted in symptom improvement within 4 days and complete scar formation within 35 days.

Conclusion

This case represents the first reported corneal infection caused by Clonostachys rosea. Antifungal treatment with natamycin, fluconazole, and terbinafine proved effective. The case contributes to clinical knowledge for diagnosis and treatment of similar fungal infections.
  • Published in:BMC Infectious Diseases,
  • Study Type:Case Report,
  • Source: PMID: 40240986, DOI: 10.1186/s12879-025-10903-9
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