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β-1,6-Glucan from Pleurotus eryngii Modulates the Immunity and Gut Microbiota

Summary

This research examined how a compound extracted from king trumpet mushrooms can boost the immune system and improve gut health. The study found that this natural compound helps strengthen immunity while promoting good bacteria growth in the gut. Impacts on everyday life: – Provides evidence for using mushrooms as natural immune boosters – Suggests new ways to improve gut health through diet – Offers potential for developing new immune-supporting supplements – Demonstrates how common edible mushrooms can have therapeutic benefits – Shows promise for developing natural alternatives to conventional medicines

Background

Pleurotus eryngii (king trumpet mushroom) has been widely used as an edible mushroom with various health benefits including anti-inflammatory, antioxidant, antitumor and antibacterial properties. These effects are attributed to active ingredients like polysaccharides, peptides, and sterols. β-1,6-glucan is an important component of fungal cell walls that has shown immunomodulatory, anti-tumor and anti-oxidant activities.

Objective

To obtain a homogeneous branched β-1,6-glucan (APEP-A-b) from P. eryngii fruiting bodies and investigate its effects on immunity and gut microbiota in mice.

Results

APEP-A-b significantly increased splenic lymphocyte proliferation, NK cell activity and phagocytic capacity of peritoneal cavity phagocytes. The proportion of CD4+ and CD8+ T cells in lamina propria increased significantly. Treatment led to increased abundance of beneficial bacteria like Lachnospiraceae and Rikenellaceae families, while reducing pathogenic bacteria. APEP-A-b also increased concentrations of acetic and butyric acid in cecum contents.

Conclusion

The β-1,6-glucan isolated from P. eryngii enhances immunity by modulating gut microbiota composition and metabolites. The 200 mg/kg·d dose showed optimal immunomodulatory effects. These findings provide insights for developing β-1,6-glucan as a therapeutic agent to enhance immunity.
  • Published in:Frontiers in Immunology,
  • Study Type:Experimental Study,
  • Source: 10.3389/fimmu.2022.859923
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