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Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

Summary

Researchers studied urinary tract infections caused by yeast (Candida species) in hospitalized patients. Using advanced molecular testing, they found that while the common yeast Candida albicans was most prevalent, other yeast species were increasingly showing resistance to antifungal medications, particularly to fluconazole. The study highlights the importance of identifying which specific yeast species is causing an infection to choose the most effective treatment.

Background

Candiduria caused by Candida species has been increasing, with rising cases of antifungal-resistant non-albicans Candida (NAC) species. Accurate species identification and antifungal susceptibility testing are crucial for proper clinical management of these infections.

Objective

To assess the prevalence and antifungal susceptibility patterns of Candida isolates from patients with candiduria using a 21-plex PCR assay and determine minimum inhibitory concentrations for fluconazole, amphotericin B, and caspofungin.

Results

Candida albicans was predominant at 70%, followed by C. tropicalis (11%), C. glabrata (9%), and C. parapsilosis (5%). Fluconazole resistance was observed in 2.86% of C. albicans isolates versus 29.41% of NAC species. NAC species showed higher resistance rates overall compared to C. albicans.

Conclusion

Candida albicans remains the predominant cause of candiduria, but NAC species demonstrate notably higher antifungal resistance, particularly to fluconazole. The 21-plex PCR system proved successful for species identification and should be employed alongside susceptibility testing for optimal clinical management.
  • Published in:Current Medical Mycology,
  • Study Type:Cross-sectional observational study,
  • Source: PMID: 41122123
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