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Electrospun Membranes Loaded with Melanin Derived from Pecan Nutshell (Carya illinoinensis) Residues for Skin-Care Applications

Summary

Researchers developed new skincare membranes by combining pecan shell waste with advanced fiber technology. These membranes harness melanin from the shells to create materials with strong antioxidant and antibacterial properties that could protect skin from aging and infections. The innovation demonstrates how agricultural waste can be transformed into valuable cosmetic products that are both effective and environmentally friendly.

Background

Skin is continuously exposed to environmental stressors that trigger degradation and aging processes. Natural bioactive compounds from agricultural residues offer sustainable alternatives for cosmetic applications. Melanin extracted from pecan nutshell waste possesses antioxidant and antifungal properties suitable for incorporation into biomaterials.

Objective

This study investigates the incorporation of melanin from pecan nutshell residues into polyacrylonitrile (PAN) fibers via electrospinning at varying concentrations (0.5%, 2.0%, and 5.0% w/w). The research aims to evaluate the physicochemical properties and biological activities of these melanin-loaded membranes for skin-care applications.

Results

Melanin-loaded fibers exhibited antioxidant activity against DPPH (46.58-62.77%) and ABTS (41.02-82.36%) radicals and demonstrated antimicrobial effects against E. coli, S. aureus, and P. aeruginosa. The membranes inhibited aging enzymes: collagenase (37%), hyaluronidase (22%), tyrosinase (36%), and elastase (33%). Molecular docking revealed strong binding interactions between melanin and enzyme active sites.

Conclusion

Melanin-loaded PAN membranes represent a promising novel biomaterial for skin-care applications, combining sustainability with potent bioactive properties. The fibers demonstrate significant antioxidant, antimicrobial, and antiaging activities suitable for wound dressing and cosmetic formulations. Further development could optimize these materials for commercial skin-care applications.
  • Published in:Membranes (Basel),
  • Study Type:Experimental Research,
  • Source: PMID: 39997671
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