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Assessment of Lab4P Probiotic Effects on Cognition in 3xTg-AD Alzheimer’s Disease Model Mice and the SH-SY5Y Neuronal Cell Line

Summary

Researchers tested a probiotic supplement called Lab4P on mice genetically engineered to develop Alzheimer’s-like symptoms and on human brain cells exposed to damaging proteins. The supplement successfully improved memory and cognitive function in the mice while protecting brain cells from damage, with stronger benefits when the mice were also on a high-fat diet. These findings suggest that probiotics might help prevent or slow cognitive decline related to Alzheimer’s disease.

Background

Aging and metabolic syndrome are associated with neurodegenerative pathologies including Alzheimer’s disease. There is growing interest in the prophylactic potential of probiotic bacteria in combating neurocognitive decline. The gut-microbiota-brain axis plays a key role in the progression of neurodegenerative conditions.

Objective

To assess the neuroprotective potential of the Lab4P probiotic consortium in age and metabolically challenged 3xTg-AD mice and human SH-SY5Y cell culture models of neurodegeneration. The study aimed to determine if Lab4P supplementation could prevent cognitive decline and neuronal degeneration.

Results

Lab4P supplementation prevented disease-associated deteriorations in novel object recognition and hippocampal neurone spine density in both chow-fed and HFD-fed mice, with more notable anti-inflammatory effects in metabolically challenged animals. In differentiated human SH-SY5Y neurons, probiotic metabolites elicited neuroprotective capability against β-Amyloid toxicity. mRNA analysis showed reduced pro-inflammatory cytokine expression in probiotic-treated animals.

Conclusion

Lab4P demonstrates potential as a neuroprotective agent in both mouse models of Alzheimer’s disease and human neuronal cell systems. The results support additional studies in animal models of neurodegenerative conditions and human clinical trials to validate the prophylactic potential of probiotic supplementation.
  • Published in:International Journal of Molecular Sciences,
  • Study Type:Preclinical In Vivo and In Vitro Study,
  • Source: PMID: 36902113, DOI: 10.3390/ijms24054683
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