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Biosynthesis of bimetallic silver–copper oxide nanoparticles using endophytic Clonostachys rosea ZMS36 and their biomedical applications

Summary

Scientists discovered a special fungus living inside a medicinal plant that can create tiny silver-copper nanoparticles with powerful antibacterial and anti-cancer properties. These nanoparticles successfully fought dangerous bacteria like MRSA and slowed the growth of cancer cells while being safe to healthy cells. This green manufacturing method is much more environmentally friendly than traditional chemical approaches and could lead to new treatments for infections and cancer.

Background

Bimetallic nanoparticles (BMNPs) have exceptional physicochemical properties and potential biomedical applications. However, there are few reports of BMNP biosynthesis using endophytic fungi from medicinal plants. This study utilizes endophytic fungi from the medicinal plant Anemarrhena asphodeloides to synthesize bimetallic Ag-CuO nanoparticles.

Objective

To isolate endophytic fungi from Anemarrhena asphodeloides, synthesize bimetallic Ag-CuO nanoparticles using the isolated fungus, characterize the biosynthesized nanoparticles, and assess their bioactivity and biosafety for biomedical applications.

Results

Strain ZMS36 was identified as Clonostachys rosea and successfully synthesized Ag-CuO NPs with an average size of 36.63 nm. The nanoparticles exhibited good antibacterial activity against six pathogens and strong inhibition of MRSA, especially in combination with vancomycin. Ag-CuO NPs showed significant anticancer activity against HeLa, PDSF, and A549 cells with IC50 values of 7.53, 35.03, and 14.93 μg/mL respectively, and inhibited cell migration and angiogenesis.

Conclusion

This study demonstrates the potential of endophytic fungi from medicinal plants to synthesize BMNPs with promising antibacterial and anticancer properties. Biosynthetic Ag-CuO NPs represent novel nanodrugs with good biocompatibility and low cytotoxicity, offering sustainable alternatives to chemical synthesis methods for future biomedical applications.
  • Published in:Frontiers in Microbiology,
  • Study Type:Experimental Research,
  • Source: 40415926
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