MYCOLab Ai Logo - gold and army green

Neutral Polysaccharides From Hohenbuehelia serotina With Hypoglycemic Effects in a Type 2 Diabetic Mouse Model

Summary

Researchers extracted and studied special compounds called polysaccharides from H. serotina mushrooms. They found that these compounds significantly reduced blood sugar levels in mice with type 2 diabetes and also protected the liver. The study shows that mushroom polysaccharides could be a safe, natural alternative to existing diabetes medications with fewer side effects.

Background

Diabetes mellitus is a chronic metabolic disease with increasing prevalence worldwide. Current hypoglycemic agents often have undesirable side effects. Mushroom polysaccharides have demonstrated various beneficial biological effects including immunomodulatory, antitumor, and hypoglycemic properties.

Objective

To purify and characterize neutral polysaccharides from Hohenbuehelia serotina and investigate their hypoglycemic effects in a type 2 diabetic mouse model while analyzing the relationship between chemical structure and biological function.

Results

NHSP had weight-average molecular weight of 1,821 kDa and was composed of glucose, galactose, and mannose in molar ratio 2.6:2.1:1.0. Structural analysis revealed mainly 1,3-linked and 1,4-linked β-D-glucose, and 1,6-linked mannose and galactose. NHSP at 200 mg/kg significantly reduced blood glucose levels and liver index in diabetic mice without affecting body weight.

Conclusion

NHSP from H. serotina displays significant hypoglycemic effects and liver-protective properties in type 2 diabetic mice. The hypoglycemic activity is associated with the polysaccharide’s composition of glucose, galactose, and mannose and its high content of β-glycosidic bonds. These findings provide a basis for further clinical applications of NHSP in diabetes management.
  • Published in:Frontiers in Pharmacology,
  • Study Type:In vivo Animal Study,
  • Source: 10.3389/fphar.2022.883653; PMID: 35600885
Scroll to Top