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Functionalized Micellar Membranes from Medicinal Mushrooms as Promising Self-Growing Bioscaffolds

Summary

Researchers created special membranes from medicinal mushrooms that could be used for wound healing and skin repairs. These membranes were grown in laboratory conditions and then treated with mango peel extract, which gave them antimicrobial properties to fight bacteria. The membranes are biodegradable, environmentally friendly, and work similar to the structure of skin tissue, making them promising for medical applications.

Background

Micellar membranes from medicinal mushrooms are self-growing fibrous polymeric biocomposites that are biocompatible, biodegradable, cost-effective, and environmentally friendly. These materials show promise for biomedical applications including tissue engineering and wound healing due to their fibrous structure resembling the skin’s extracellular matrix.

Objective

To optimize the cultivation of Ganoderma lucidum and Pleurotus ostreatus via submerged cultivation to maximize micellar membrane growth and water-absorption capacity. Additionally, to functionalize these membranes with mango peel extract to enhance therapeutic potential and evaluate their antimicrobial properties.

Results

Optimal growth conditions were achieved at alkaline pH in malt extract medium for G. lucidum and glucose-enriched medium for P. ostreatus. The membranes exhibited high water-absorption capacity (up to 608% for P. ostreatus), fibrous and porous structure, and thermal stability above 260°C. MPE-functionalized membranes showed uniform release profiles and significant antimicrobial activity against E. coli and S. aureus.

Conclusion

Functionalized micellar membranes from medicinal mushrooms represent innovative biocomposites suitable for biomedical applications. Their ability to mimic the extracellular matrix of skin combined with antimicrobial properties and controlled bioactive release make them promising materials for tissue engineering, wound healing, and advanced skin applications.
  • Published in:Polymers (Basel),
  • Study Type:Experimental Research,
  • Source: PMID: 40942252, DOI: 10.3390/polym17172334
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