MYCOLab Ai Logo - gold and army green

Microfungus Podosphaera fusca and the Fungus-like Organism Peronospora ficariae as Potential Inhalant Allergens in a Mouse Model of Asthma

Summary

This study found that two types of plant fungi, Podosphaera fusca and Peronospora ficariae, can trigger asthma-like reactions in mice similar to known allergens. While these fungi produce weaker responses than the standard allergen ovalbumin, they still cause significant inflammation, immune activation, and airway changes. The research suggests these plant parasites should be added to the list of recognized allergens that may trigger respiratory problems in humans.

Background

Allergic conditions affect approximately 30% of the global population, with fungi accounting for about 6% of respiratory issues. Identifying causes of respiratory allergies remains challenging as standard diagnostic tests often fail to pinpoint specific allergens. This study investigates two previously unexplored plant parasites as potential inhalant allergens.

Objective

To assess the capacity of Podosphaera fusca and Peronospora ficariae to provoke inflammatory and asthmatic reactions in mouse models of acute and chronic asthma. The study aimed to measure pro-inflammatory cytokines, specific IgE production, and histological changes in mouse lungs.

Results

Both P. fusca and P. ficariae induced significant production of all tested cytokines, increased specific IgE levels, and caused histological changes characteristic of asthma progression in both acute and chronic models. Although weaker than ovalbumin, both fungi demonstrated proinflammatory and asthma-inducing capabilities, with P. ficariae showing stronger effects than P. fusca.

Conclusion

P. fusca and P. ficariae possess allergenic potential comparable to established fungal allergens, though less potent than ovalbumin. These findings support expanding the list of recognized fungal allergens and suggest these plant parasites should be considered as potential sources of respiratory allergies in humans.
  • Published in:Cells,
  • Study Type:Experimental Animal Model Study,
  • Source: PMC12190413, PMID: 40558541
Scroll to Top