MYCOLab Ai Logo - gold and army green

Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review

Summary

Lion’s Mane mushroom shows promising benefits for brain health, potentially improving memory and reducing symptoms of anxiety and depression. It may help prevent cancer by triggering cancer cell death and supports digestive health by promoting beneficial gut bacteria. While generally safe, some people experience mild side effects like stomach discomfort or headaches, making it an accessible supplement for overall wellness.

Background

Hericium erinaceus (Lion’s Mane mushroom) is an edible, medicinal fungus containing bioactive polysaccharides and erinacines. It exhibits neuroprotective, anti-tumor, antioxidant, anti-proliferative, and anti-inflammatory effects through stimulation of nerve growth factor and brain-derived neurotrophic factor synthesis.

Objective

This systematic review investigates existing literature on the clinical use of Hericium erinaceus, outlining its benefits and side effects related to neural stimulation, apoptotic activity, short-chain fatty acid-producing microbiota, and mood dysregulation. The aim is to establish a comprehensive safety profile for the supplement.

Results

The review includes 5 randomized controlled trials, 15 laboratory studies, 3 pilot clinical trials, 1 cohort study, 1 case report, and 1 computer analysis. Mini-Mental State Examination scores showed combined weighted mean increase of 1.17 in intervention groups. Laboratory studies demonstrated erinacine A inhibited cancer cell invasiveness and activated apoptotic pathways. Hericium erinaceus increased gut microbiota diversity and SCFA-producing bacteria while reducing inflammation.

Conclusion

Hericium erinaceus is effective in neuroprotection, cognitive enhancement, cancer prevention, gut health promotion, and symptom improvement for anxiety and depression. Although uncommon, potential side effects include stomach discomfort, headache, and allergic reactions. Further clinical trials are needed to validate findings and establish optimal dosing protocols.
  • Published in:Frontiers in Nutrition,
  • Study Type:Systematic Review,
  • Source: 40959699
Scroll to Top