MYCOLab Ai Logo - gold and army green

Process Optimization for the Bioinspired Synthesis of Gold Nanoparticles Using Cordyceps militaris, Its Characterization, and Assessment of Enhanced Therapeutic Efficacy

Summary

Scientists successfully created tiny gold particles using an edible mushroom called Cordyceps militaris instead of harsh chemicals. These gold nanoparticles are incredibly small (just 7 nanometers) and showed impressive healing potential against bacteria, diabetes-related enzymes, and even cancer cells in lab tests. The method is environmentally friendly, safe, and could lead to new medical treatments.

Background

Gold nanoparticles have promising therapeutic applications in biomedical fields. Eco-friendly synthesis methods using biological sources are preferred over chemical methods to avoid toxic byproducts. Cordyceps militaris, an edible mushroom enriched with bioactive compounds, offers a sustainable alternative for green nanoparticle synthesis.

Objective

To optimize the eco-friendly synthesis of gold nanoparticles using Cordyceps militaris extract through a quality-by-design approach, characterize the synthesized nanoparticles, and assess their therapeutic efficacy in antioxidant, antidiabetic, and antibacterial applications.

Results

Optimization yielded gold nanoparticles with mean particle size of 7.18 nm and zeta potential of -19.42 mV, confirming stability. UV-vis spectroscopy confirmed synthesis with absorption peak at 540-550 nm. Cord-Au-NPs exhibited dose-dependent antioxidant, antidiabetic, and antibacterial activities comparable to or exceeding standard compounds, with cytotoxicity against cancer cell lines.

Conclusion

The green synthesis of gold nanoparticles using Cordyceps militaris is eco-friendly, non-toxic, and efficient. The resulting nanoparticles demonstrate significant biomedical potential with antioxidant, antidiabetic, and antibacterial properties suitable for therapeutic applications.
  • Published in:Pharmaceuticals (Basel),
  • Study Type:Experimental Research,
  • Source: 10.3390/ph16091311; PMID: 37765119
Scroll to Top