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Functionalized Micellar Membranes from Medicinal Mushrooms as Promising Self-Growing Bioscaffolds

Summary

Scientists created special membranes from medicinal mushrooms that can help heal wounds and regenerate damaged skin. These membranes are grown naturally in liquid culture and enriched with extract from mango peels to fight bacteria and promote healing. The material is completely natural, biodegradable, and performs better than many conventional wound healing materials, making it an eco-friendly option for medical applications.

Background

Micellar membranes from medicinal mushrooms are self-growing fibrous polymeric biocomposites that are biocompatible, biodegradable, and environmentally friendly. These materials offer a cost-effective alternative to conventional biocomposites for biomedical applications. Traditional biopolymeric materials synthesis is expensive and time-consuming, making mushroom-derived materials an attractive sustainable solution.

Objective

The study aimed to optimize cultivation conditions for Ganoderma lucidum and Pleurotus ostreatus to maximize micellar membrane formation and water-absorption capacity. The researchers functionalized these membranes with mango peel extract (MPE) to enhance therapeutic potential and evaluated their antimicrobial properties for biomedical applications including wound healing and tissue engineering.

Results

Optimal growth conditions were alkaline pH with malt extract medium for G. lucidum and glucose-enriched medium for P. ostreatus. The membranes exhibited high water-absorption capacity (up to 608.1%), broad spectrum of functional groups, thermal stability above 260°C, and fibrous porous structure. MPE-functionalized membranes showed uniform gradual release profiles and successful antimicrobial activity against both bacterial species tested.

Conclusion

Functionalized micellar membranes from medicinal mushrooms are innovative biocomposites suitable for various biomedical applications, particularly tissue engineering and wound healing. The incorporation of mango peel extract adds therapeutic value while utilizing agricultural waste. These self-growing bioscaffolds represent a sustainable and cost-effective alternative to conventional biomaterials for regenerative medicine applications.
  • Published in:Polymers (Basel),
  • Study Type:Experimental Research,
  • Source: PMID: 40942252, DOI: 10.3390/polym17172334
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