Impacts of selenium enrichment on nutritive value and obesity prevention of Cordyceps militaris: A nutritional, secondary metabolite, and network pharmacological analysis
- Author: mycolabadmin
- 7/12/2023
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Summary
Researchers studied how adding selenium to Cordyceps militaris mushrooms affects their nutritional value and ability to prevent obesity. They found that selenium enrichment increased the mushroom’s carbohydrates and fiber content, and enhanced beneficial compounds like terpenoids and alkaloids. In mice fed a high-fat diet, both regular and selenium-enriched Cordyceps militaris reduced weight gain and improved metabolic health equally well. The study suggests these mushrooms work against obesity by using multiple active compounds that target different biological pathways simultaneously.
Background
Cordyceps militaris is a precious edible and medicinal mushroom with multiple bioactivities including anti-obesity effects. Selenium is a nutritionally essential trace element that may enhance the nutritional value of foods through enrichment. Limited understanding exists regarding the comprehensive impacts of selenium enrichment on the nutritive value and bioactivities of Cordyceps militaris.
Objective
This study aimed to compare the nutritive value and obesity prevention effects of ordinary Cordyceps militaris and selenium-enriched Cordyceps militaris through nutritional analysis, secondary metabolite profiling, and network pharmacological approaches.
Results
Selenium enrichment significantly increased total carbohydrates, soluble dietary fiber, and secondary metabolites (terpenoids and alkaloids) while decreasing protein and insoluble dietary fiber. Both CM and SeCM reduced body weight, adipose accumulation, glucose intolerance, and lipid levels in HFD-fed mice with no significant differences between them. Network analysis revealed 52 bioactive ingredients and 87 molecular targets, with genistein, melatonin, and capsaicin acting on MAPK1, TP53, and TSHR through MAPK signaling pathways.
Conclusion
Selenium enrichment improves the nutritive value of Cordyceps militaris at macro and micro levels without altering its obesity prevention effects. The preventive effects are mediated by multiple ingredients acting on multiple targets through MAPK signaling pathway regulation, providing a foundation for therapeutic potential in obesity prevention.
- Published in:Food Chemistry X,
- Study Type:Experimental/Comparative Study,
- Source: PMID: 37780281, DOI: 10.1016/j.fochx.2023.100788