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Antrodia Camphorata Supplement in the Early Life Inhibits Intestinal Tumorigenesis Later in Young Adult APC1638N Mice

Summary

Researchers found that a mushroom supplement called Antrodia camphorate, when given to mice during childhood and adolescence, helped prevent intestinal tumors when the mice reached young adulthood. This effect was especially strong in mice that ate a high-fat diet early in life. The supplement appears to work by reducing inflammation and blocking certain proteins involved in tumor growth.

Background

Colorectal cancer shows increasing incidence in young adults in the U.S., with early-life nutrition playing a significant role in disease development. Antrodia camphorate mushroom has demonstrated promising anti-inflammatory and anti-tumorigenesis properties in limited studies.

Objective

To investigate the effects of Antrodia camphorate supplementation added to a high-fat diet during early life on the development of intestinal tumorigenesis in young adult APC1638N mice.

Results

AC supplement suppressed tumor incidence and multiplicity, particularly in female mice. AC decreased gene expressions of inflammatory mediators and IGF1-related factors, and attenuated phospho-MEK, phospho-ERK1/2, phosph-GSK-3β, and β-catenin protein expression in intestinal tissues of HFD-fed mice.

Conclusion

AC supplement during early life exhibits potential capabilities to inhibit intestinal tumorigenesis in young adult mice, with particularly evident effects in mice fed high-fat diet during early life.
  • Published in:Current Developments in Nutrition,
  • Study Type:Animal Study,
  • Source: PMC9193504
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