Single-center retrospective analysis of 454 culture-positive patients with tinea capitis and measurement of pathogens regarding thermal tolerance at 37°C
- Author: mycolabadmin
- 8/25/2025
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Summary
Tinea capitis, commonly known as scalp ringworm, is a fungal infection that primarily affects children but can also occur in adults, especially postmenopausal women. This study of 454 patients in Hangzhou, China found that the most common cause is Microsporum canis (a fungus from cats and dogs), representing a shift from previous decades when different fungi were dominant. Researchers tested how well these fungi grow at human body temperature (37°C) versus room temperature, finding that most fungi adapt well to the warmer temperature, particularly Nannizzia gypsea, which grew equally well at both temperatures. Treatment typically involves oral antifungal medications like terbinafine or itraconazole, sometimes combined with topical treatments or steroids for inflammatory cases.
Background
Tinea capitis (TC) is a dermatophyte infection affecting hair and scalp, primarily occurring in preadolescent children but sometimes affecting adults. The pathogenic spectrum of TC varies geographically and has undergone marked changes in Hangzhou over the past decade. Previous studies suggested that pathogenicity of fungi is positively correlated with 37°C tolerance.
Objective
This study aimed to analyze the epidemiological characteristics of tinea capitis and the changing trend of pathogenic fungal spectrum in Hangzhou. The study also sought to assess the thermal tolerance of pathogenic dermatophytes at 37°C, reflecting mammalian body temperature.
Results
Microsporum canis was the dominant pathogen (68.50%), followed by Trichophyton violaceum (10.57%), T. tonsurans (7.71%), and T. mentagrophytes complex (6.61%). Among children, M. canis accounted for 73.43% of cases, while in adults it was 32.73%. Most dermatophytes grew well at 37°C, with all 10 strains of Nannizzia gypsea showing excellent thermal tolerance.
Conclusion
Microsporum canis is the dominant pathogen of TC in Hangzhou. Elderly postmenopausal women are the main affected group for adult TC, and anthropophilic dermatophytes are more prevalent in adults. Most dermatophytes demonstrate good thermal tolerance at 37°C, suggesting an adaptive mechanism for human infection.
- Published in:Frontiers in Medicine,
- Study Type:Retrospective Cohort Study,
- Source: PMID: 40927194, DOI: 10.3389/fmed.2025.1550270