Two Cases of Curvularia geniculata Keratitis Successfully Treated with Natamycin-Based Therapy
- Author: mycolabadmin
- 9/13/2025
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Summary
Two patients with eye infections caused by a rare fungal species called Curvularia geniculata were successfully treated with antifungal medication. The infections occurred after plant material entered their eyes during daily activities. Doctors identified the exact fungal species through genetic testing and used an antifungal drug called natamycin, alone or combined with another antifungal, to treat the infections. Both patients recovered fully with excellent vision restoration.
Background
Fungal keratitis caused by dematiaceous fungi including Curvularia species is a significant cause of visual impairment worldwide, particularly following plant-related ocular trauma. Curvularia geniculata keratitis is relatively rare with limited knowledge of its clinical features and treatment options.
Objective
To report two cases of molecularly confirmed Curvularia geniculata keratitis and evaluate the efficacy of natamycin-based therapy. The authors aimed to contribute to understanding of the clinical features, diagnosis, and management of this uncommon fungal infection.
Results
Both isolates were confirmed as Curvularia geniculata through molecular identification showing 100% identity with reference strain. Both isolates demonstrated sensitivity to natamycin at 2 μg/mL. Patient 1 was treated with natamycin and voriconazole combination therapy achieving 20/20 visual acuity, while Patient 2 was treated with natamycin monotherapy achieving 20/16 visual acuity. Both patients achieved complete healing with excellent visual outcomes.
Conclusion
- Published in:Mycopathologia,
- Study Type:Case Report,
- Source: PMID: 40944879, DOI: 10.1007/s11046-025-00997-9